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Harmonization study between three laboratories for expression of malaria vaccine clinical trial IgG antibody ELISA data in µg/mL

Abstract:

Background The ability to report vaccine-induced IgG responses in terms of µg/mL, as opposed arbitrary units (AU), enables a more informed interpretation of the magnitude of the immune response, and better comparison between vaccines targeting different antigens. However, these interpretations rely on the accuracy of the methodology, which is used to generate ELISA data in µg/mL. In a previous clinical trial of a vaccine targeting the apical membrane antigen 1 (AMA1) from ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1186/s12936-019-2935-3

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal Journal website
Volume:
18
Article number:
300
Publication date:
2019-09-02
Acceptance date:
2019-08-24
DOI:
EISSN:
1475-2875
Pmid:
31477111
Language:
English
Pubs id:
pubs:1049469
UUID:
uuid:03e0b5a7-aff5-4f40-b9ac-05f720c65529
Local pid:
pubs:1049469
Source identifiers:
1049469
Deposit date:
2019-09-17

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