- Abstract:
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The T cell compartment must contain diversity in both T cell receptor (TCR) repertoire and cell state to provide effective immunity against pathogens. However, it remains unclear how differences in the TCR contribute to heterogeneity in T cell state. Single cell RNA-sequencing (scRNA-seq) can allow simultaneous measurement of TCR sequence and global transcriptional profile from single cells. However, current methods for TCR inference from scRNA-seq are limited in their sensitivity and require...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.5MB)
-
- Publisher copy:
- 10.1093/nar/gkx615
-
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- Grant:
- L.S. as an MRC CASE studentship (to L.S and E.B)
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Nucleic Acids Research Journal website
- Volume:
- 45
- Issue:
- 16
- Pages:
- e148
- Publication date:
- 2017-07-17
- Acceptance date:
- 2017-07-12
- DOI:
- EISSN:
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1362-4962
- ISSN:
-
0305-1048
- Pubs id:
-
pubs:732939
- URN:
-
uri:039073f8-ff3d-421c-adb7-b7ea6564cc08
- UUID:
-
uuid:039073f8-ff3d-421c-adb7-b7ea6564cc08
- Local pid:
- pubs:732939
- Paper number:
- 16
- Language:
- English
- Copyright holder:
- Afik et al.
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 The Authors. Published by Oxford University Press on behalf of Nucleic Acids Research.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal article
Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state
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