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Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state

Abstract:

The T cell compartment must contain diversity in both T cell receptor (TCR) repertoire and cell state to provide effective immunity against pathogens. However, it remains unclear how differences in the TCR contribute to heterogeneity in T cell state. Single cell RNA-sequencing (scRNA-seq) can allow simultaneous measurement of TCR sequence and global transcriptional profile from single cells. However, current methods for TCR inference from scRNA-seq are limited in their sensitivity and require...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkx615

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Grant:
L.S. as an MRC CASE studentship (to L.S and E.B)
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
45
Issue:
16
Pages:
e148
Publication date:
2017-07-17
Acceptance date:
2017-07-12
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pubs id:
pubs:732939
URN:
uri:039073f8-ff3d-421c-adb7-b7ea6564cc08
UUID:
uuid:039073f8-ff3d-421c-adb7-b7ea6564cc08
Local pid:
pubs:732939
Paper number:
16
Language:
English

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