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Autophagy dictates metabolism and differentiation of inflammatory immune cells

Abstract:

The role of macroautophagy/autophagy, a conserved lysosomal degradation pathway, during cellular differentiation has been well studied over the last decade. Particularly, evidence for its role during immune cell differentiation is growing. Despite the description of a variety of dramatic immune phenotypes in tissue-specific autophagy knockout models, the underlying mechanisms are still under debate. One of the proposed mechanisms is the impact of autophagy on the altered metabolic states duri...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1080/15548627.2017.1362525

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Department:
Oxford, MSD, NDORMS, KIR
Role:
Author
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Department:
Oxford, MSD, NDORMS, KIR
Role:
Author
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Department:
Somerville College
Role:
Author
Publisher:
Taylor and Francis Publisher's website
Journal:
Autophagy Journal website
Volume:
14
Issue:
2
Pages:
199-206
Publication date:
2017-08-14
Acceptance date:
2017-07-18
DOI:
EISSN:
1554-8635
ISSN:
1554-8627
Pubs id:
pubs:709067
URN:
uri:03905041-44c1-41a6-8e57-d4a77dc2ee8b
UUID:
uuid:03905041-44c1-41a6-8e57-d4a77dc2ee8b
Local pid:
pubs:709067

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