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Repeat controlled human malaria infection of healthy UK adults with blood-stage Plasmodium falciparum: safety and parasite growth dynamics

Abstract:

In endemic settings it is known that natural malaria immunity is gradually acquired following repeated exposures. Here we sought to assess whether similar acquisition of blood-stage malaria immunity would occur following repeated parasite exposure by controlled human malaria infection (CHMI). We report the findings of repeat homologous blood-stage Plasmodium falciparum (3D7 clone) CHMI studies VAC063C (ClinicalTrials.gov NCT03906474) and VAC063 (ClinicalTrials.gov NCT029...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.3389/fimmu.2022.984323

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Publisher:
Frontiers Media
Journal:
Frontiers in Immunology More from this journal
Volume:
13
Article number:
984323
Publication date:
2022-08-22
Acceptance date:
2022-08-01
DOI:
EISSN:
1664-3224
Pmid:
36072606
Language:
English
Keywords:
Pubs id:
1278123
Local pid:
pubs:1278123
Deposit date:
2022-12-01

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