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Effects of alteplase on survival after ischaemic stroke (IST-3): 3 year follow-up of a randomised, controlled, open-label trial

Abstract:

The effect of alteplase on patient survival after ischaemic stroke is the subject of debate. We report the effect of intravenous alteplase on long-term survival after ischaemic stroke of participants in the Third International Stroke Trial (IST-3).In IST-3, done at 156 hospitals in 12 countries (Australia, Europe, and the UK), participants (aged >18 years) were randomly assigned with a telephone voice-activated or web-based system in a 1:1 ratio to treatment with intravenous 0·9 mg/kg alte...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/s1474-4422(16)30139-9

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Role:
Author
ORCID:
0000-0002-5313-9052
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Publisher:
Elsevier Publisher's website
Journal:
Lancet Neurology Journal website
Volume:
15
Issue:
10
Pages:
1028-1034
Publication date:
2016-07-20
Acceptance date:
2016-06-13
DOI:
EISSN:
1474-4465
ISSN:
1474-4422
Pubs id:
pubs:636470
URN:
uri:036da67b-cad2-4802-95f6-66d8c476a37a
UUID:
uuid:036da67b-cad2-4802-95f6-66d8c476a37a
Local pid:
pubs:636470
Language:
English
Keywords:

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