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Global changes of the RNA-bound proteome during thematernal-to-zygotic transition in Drosophila

Abstract:

The maternal-to-zygotic transition (MZT) is a process that occurs in animal embryos at the earliest developmental stages, during which maternally deposited mRNAs and other molecules are degraded and replaced by products of the zygotic genome. The zygotic genome is not activated immediately upon fertilization, and in the pre-MZT embryo post-transcriptional control by RNA-binding proteins (RBPs) orchestrates the first steps of development. To identify relevant DrosophilaRBPs organism-wide, we r...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms12128

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Funding agency for:
Castello Palomares, A
Grant:
MR/L019434/1
European Molecular Biology Laboratory More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
7
Pages:
12128
Publication date:
2016-07-01
Acceptance date:
2016-06-03
DOI:
ISSN:
2041-1723
Source identifiers:
625270
Keywords:
Pubs id:
pubs:625270
UUID:
uuid:0341b1d6-a019-4717-8ecb-53743c563ea2
Local pid:
pubs:625270
Deposit date:
2016-08-05

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