Journal article
Investigating voice as a biomarker for leucine-rich repeat kinase 2-associated Parkinson’s disease
- Abstract:
-
We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations (‘aaah’ sounds) were recorded from 7 individuals with LRRK2-associated Parkinson’s disease (PD), 17 participants with idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation carriers, 25 related non-carriers, and 26 controls. In distinguishing LRRK2-associated PD and iPD, the mean sensitivity was 95.4% (SD 17.8%) and mean specificity was 89.6% (SD 26.5%). Voice featur...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Michael J Fox Foundation for Parkinson's Research
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Bibliographic Details
- Publisher:
- IOS Press Publisher's website
- Journal:
- Journal of Parkinson's Disease Journal website
- Volume:
- 8
- Issue:
- 4
- Pages:
- 503-510
- Publication date:
- 2018-10-17
- Acceptance date:
- 2018-08-21
- DOI:
- EISSN:
-
1877-718X
- ISSN:
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1877-7171
Item Description
- Keywords:
- Pubs id:
-
pubs:929591
- UUID:
-
uuid:033a4c9b-c837-4c6d-b346-7f761eb7e134
- Local pid:
- pubs:929591
- Source identifiers:
-
929591
- Deposit date:
- 2018-10-19
Terms of use
- Copyright holder:
- IOS Press
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 IOS Press. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from IOS Press at: http://dx.doi.org/10.3233/JPD-181389
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