Journal article
Deciphering the contribution of γδ T cells to outcomes in transplantation
- Abstract:
- γδ T cells are a subpopulation of lymphocytes expressing heterodimeric T-cell receptors composed of γ and δ chains. They are morphologically and functionally heterogeneous, innate yet also adaptive in behavior, and exhibit diverse activities spanning immunosurveillance, immunomodulation, and direct cytotoxicity. The specific responses of γδ T cells to allografts are yet to be fully elucidated with evidence of both detrimental and tolerogenic roles in different settings. Here we present an overview of γδ T-cell literature, consider ways in which their functional heterogeneity contributes to the outcomes after transplantation, and reflect on methods to harness their beneficial properties.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
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(Preview, Accepted manuscript, pdf, 2.0MB, Terms of use)
-
- Publisher copy:
- 10.1097/TP.0000000000002335
Authors
- Publisher:
- Lippincott Williams and Wilkins
- Journal:
- Transplantation More from this journal
- Volume:
- 102
- Issue:
- 12
- Pages:
- 1983–1993
- Publication date:
- 2018-07-10
- Acceptance date:
- 2018-05-31
- DOI:
- EISSN:
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1534-6080
- ISSN:
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0041-1337
- Pubs id:
-
pubs:858715
- UUID:
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uuid:031a1cf6-108b-4363-a0ef-f5097bffbffc
- Local pid:
-
pubs:858715
- Source identifiers:
-
858715
- Deposit date:
-
2018-06-21
Terms of use
- Copyright holder:
- Wolters Kluwer Health
- Copyright date:
- 2018
- Notes:
- © 2018 Wolters Kluwer Health, Inc. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Lippincott Williams and Wilkins at: https://doi.org/10.1097/TP.0000000000002335
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