Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): preliminary analysis from the united kingdom randomised, controlled open-label, platform adaptive trial

Butler, C; Hobbs, FDR; Gbinigie, O; Rahman, NM; Hayward, G; Richards, D; Dorward, J; Lowe, D; Standing, JF; Breuer, J; Khoo, S; Petrou, S; Hood, K; Nguyen-Van-Tam, JS; Patel, M; Saville, BR; Marion, J; Ogburn, E; Allen, J; Rutter, H; Francis, N; Thomas, N; Evans, P; Dobson, M; Madden, T-A; Holmes, J; Harris, V; Png, ME; Lown, M; van Hecke, O; Detry, M; Saunders, C; Fitzgerald, M; Berry, N; Mwandigha, L; Galal, U; Jani, B; Hart, N; Butler, D; Chalk, J; Lavallee, L; Hadley, E; Cureton, L; Benysek, M; Andersson, M; Coates, M; Barrett, S; Bateman, C; Davies, J; Raymundo-Wood, I

Journal article

Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): preliminary analysis from the united kingdom randomised, controlled open-label, platform adaptive trial

Abstract:: Background:
The safety, effectiveness and cost-effectiveness of molnupiravir, an oral antiviral medication for SARS-CoV-2, in patients in the community who are multiply-vaccinated and at increased risk of morbidity and mortality from COVID-19, has not been established. We aimed to determine whether molnupiravir added to usual care reduced hospital admissions/deaths among people at higher risk from COVID-19, and here report our preliminary analyses.
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Peer review status:: Not peer reviewed

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APA Style

Butler, C., Hobbs, F. D. R., Gbinigie, O., Rahman, N. M., Hayward, G., Richards, D., Dorward, J., Lowe, D., Standing, J. F., Breuer, J., Khoo, S., Petrou, S., Hood, K., Nguyen-Van-Tam, J. S., Patel, M., Saville, B. R., Marion, J., Ogburn, E., Allen, J., … Raymundo-Wood, I. (2022). Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): preliminary analysis from the united kingdom randomised, controlled open-label, platform adaptive trial. SSRN.

MLA Style

Butler, C., et al. “Molnupiravir plus Usual Care versus Usual Care Alone as Early Treatment for Adults with COVID-19 at Increased Risk of Adverse Outcomes (PANORAMIC): Preliminary Analysis from the United Kingdom Randomised, Controlled Open-Label, Platform Adaptive Trial.” SSRN, 2022.

Chicago Style

Butler, C, FDR Hobbs, O Gbinigie, NM Rahman, G Hayward, D Richards, J Dorward, et al. 2022. “Molnupiravir plus Usual Care versus Usual Care Alone as Early Treatment for Adults with COVID-19 at Increased Risk of Adverse Outcomes (PANORAMIC): Preliminary Analysis from the United Kingdom Randomised, Controlled Open-Label, Platform Adaptive Trial.” SSRN.
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Files:: Butler_et_al_2022_Molnupiravir_plus_usual.pdf

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Publisher copy:: 10.2139/ssrn.4237902

Authors

+ Butler, C More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Primary Care Health Sciences
Oxford college:: Trinity College
Role:: Author
ORCID:: 0000-0002-0102-3453

+ Hobbs, FDR More by this author

Role:: Author

+ Gbinigie, O More by this author

Role:: Author

+ Rahman, NM More by this author

Role:: Author

+ Hayward, G More by this author

Role:: Author

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+ National Institute for Health Research More from this funder

Grant:: NF-SI-0515-10056

Journal:: SSRN More from this journal
Publication date:: 2022-10-04
DOI:: 10.2139/ssrn.4237902
EISSN:: 1556-5068

Language:: English
Keywords:: molnupiravir

COVID-19

antiviral agents

primary health care

clincial trial

FFR
Pubs id:: 1310768
Local pid:: pubs:1310768
Deposit date:: 2023-01-31

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Copyright holder:: Butler et al.

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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Journal article

Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): preliminary analysis from the united kingdom randomised, controlled open-label, platform adaptive trial

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Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): preliminary analysis from the united kingdom randomised, controlled open-label, platform adaptive trial

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