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Blood eosinophils: a biomarker of COPD exacerbation reduction with inhaled corticosteroids

Abstract:

Background

Growing evidence suggests that blood eosinophil count is associated with patient responsiveness to inhaled corticosteroids (ICS). We performed post hoc predictive modeling on data from the FORWARD study and two replicate studies by Dransfield, to evaluate the relationships between baseline eosinophil count and the effect of ICS on exacerbations and lung function in patients with COPD.

Methods

The studies assessed ICS/long-acting β2 agonist (LABA) combin...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.2147/COPD.S179425

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Strategic
Oxford college:
St Edmund Hall
Role:
Author
ORCID:
0000-0002-4288-5973
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GlaxoSmithKline More from this funder
Chiesi Farmaceutici SpA More from this funder
National Institute for Health Research More from this funder
Publisher:
Dove Press Publisher's website
Journal:
International Journal of Chronic Obstructive Pulmonary Disease Journal website
Volume:
13
Pages:
3669-3676
Publication date:
2018-11-06
Acceptance date:
2018-10-12
DOI:
ISSN:
1176-9106 and 1178-2005
Pubs id:
pubs:949005
URN:
uri:02e4a6b8-3142-4626-af8e-03201f47a67e
UUID:
uuid:02e4a6b8-3142-4626-af8e-03201f47a67e
Local pid:
pubs:949005
Language:
English
Keywords:

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