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Journal article

PGBD5 promotes site-specific oncogenic mutations in human tumors

Abstract:

Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase expressed in the majority of childhood solid tumors, including lethal rhabdoid tumors. Using assembly-based whole-genome DNA sequencing, we found previously undefined genomic rearrangements in human rhabdoid tumors. These rearrangements involved PGBD5-specific signal (PSS) sequences at their breakpoints and recurrently inactiv...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Files:
Publisher copy:
10.1038/ng.3866

Authors


Henssen, AG More by this author
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Grant:
K08 CA160660, P30 CA008748, U54 OD020355, UL1 TR000457, P50 CA140146
Cancer Research UK More from this funder
Starr Cancer Consortium More from this funder
Burroughs Wellcome Fund More from this funder
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Genetics Journal website
Volume:
49
Pages:
1005–1014
Publication date:
2017-05-15
Acceptance date:
2017-04-18
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pubs id:
pubs:695571
URN:
uri:02c7fe8a-6230-49ae-a950-44ae18a18bff
UUID:
uuid:02c7fe8a-6230-49ae-a950-44ae18a18bff
Local pid:
pubs:695571
Language:
English
Keywords:

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