Journal article icon

Journal article

PGBD5 promotes site-specific oncogenic mutations in human tumors

Abstract:

Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase expressed in the majority of childhood solid tumors, including lethal rhabdoid tumors. Using assembly-based whole-genome DNA sequencing, we found previously undefined genomic rearrangements in human rhabdoid tumors. These rearrangements involved PGBD5-specific signal (PSS) sequences at their breakpoints and recurrently inactiv...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/ng.3866

Authors


Expand authors...
Cancer Research UK More from this funder
More from this funder
Grant:
K08 CA160660, P30 CA008748, U54 OD020355, UL1 TR000457, P50 CA140146
Burroughs Wellcome Fund More from this funder
Starr Cancer Consortium More from this funder
Expand funders...
Publisher:
Springer Nature Publisher's website
Journal:
Nature Genetics Journal website
Volume:
49
Pages:
1005–1014
Publication date:
2017-05-15
Acceptance date:
2017-04-18
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Source identifiers:
695571
Language:
English
Keywords:
Pubs id:
pubs:695571
UUID:
uuid:02c7fe8a-6230-49ae-a950-44ae18a18bff
Local pid:
pubs:695571
Deposit date:
2017-05-18

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP