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Tuning transcription factor availability through acetylation-mediated genomic redistribution

Abstract:

It is widely assumed that decreasing transcription factor DNA-binding affinity reduces transcription initiation by diminishing occupancy of sequence-specific regulatory elements. However, in vivo transcription factors find their binding sites while confronted with a large excess of low-affinity degenerate motifs. Here, using the melanoma lineage survival oncogene MITF as a model, we show that low-affinity binding sites act as a competitive reservoir in vivo from which transcription factors ar...

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Publication status:
In press
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.molcel.2020.05.025

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
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Ludwig Institute for Cancer Research More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Molecular Cell Journal website
Publication date:
2020-06-11
Acceptance date:
2020-05-19
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Language:
English
Keywords:
Pubs id:
1105517
Local pid:
pubs:1105517
Deposit date:
2020-05-19

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