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A mechanism for the activation of the influenza virus transcriptase

Abstract:

Influenza virus RNA polymerase (FluPol), a heterotrimer composed of PB1, PB2, and PA subunits (P3 in influenza C), performs both transcription and replication of the viral RNA genome. For transcription, FluPol interacts with the C-terminal domain (CTD) of RNA polymerase II (Pol II), which enables FluPol to snatch capped RNA primers from nascent host RNAs. Here, we describe the co-crystal structure of influenza C virus polymerase (FluPolC) bound to a Ser5-phosphorylated CTD (pS5-CTD) peptide. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.molcel.2018.05.011

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
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Funding agency for:
Serna Martin, I
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Funding agency for:
Hengrung, N
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Funding agency for:
Martinez Alonso, M
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Funding agency for:
Masiulis, S
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Publisher:
Elsevier Publisher's website
Journal:
Molecular Cell Journal website
Volume:
70
Issue:
6
Pages:
1101–1110.e4
Publication date:
2018-06-14
Acceptance date:
2018-05-08
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Pubs id:
pubs:853057
URN:
uri:028fb37f-abda-4154-9f71-811ded69fcbf
UUID:
uuid:028fb37f-abda-4154-9f71-811ded69fcbf
Local pid:
pubs:853057

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