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Journal article

Viral persistence, liver disease, and host response in a hepatitis C–like virus rat model

Abstract:

The lack of a relevant, tractable, and immunocompetent animal model for hepatitis C virus (HCV) has severely impeded investigations of viral persistence, immunity, and pathogenesis. In the absence of immunocompetent models with robust HCV infection, homolog hepaciviruses in their natural host could potentially provide useful surrogate models. We isolated a rodent hepacivirus from wild rats (Rattus norvegicus), RHV‐rn1; acquired the complete viral genome sequence; and developed an infectious r...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/hep.29494

Authors


Trivedi, S More by this author
Hartlage, AS More by this author
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Grant:
NNF14OC0012533
NNF15OC0017404
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Grant:
R21 AI107631
R01 AI131688
Publisher:
American Association for the Study of Liver Disease Publisher's website
Journal:
Hepatology Journal website
Volume:
60
Issue:
2
Pages:
435-448
Publication date:
2017-08-31
Acceptance date:
2017-08-27
DOI:
EISSN:
1527-3350
ISSN:
0270-9139
Pubs id:
pubs:724992
URN:
uri:0267b574-510f-4743-b9dd-2d67136e0516
UUID:
uuid:0267b574-510f-4743-b9dd-2d67136e0516
Local pid:
pubs:724992

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