Journal article
Viral persistence, liver disease, and host response in a hepatitis C–like virus rat model
- Abstract:
-
The lack of a relevant, tractable, and immunocompetent animal model for hepatitis C virus (HCV) has severely impeded investigations of viral persistence, immunity, and pathogenesis. In the absence of immunocompetent models with robust HCV infection, homolog hepaciviruses in their natural host could potentially provide useful surrogate models. We isolated a rodent hepacivirus from wild rats (Rattus norvegicus), RHV‐rn1; acquired the complete viral genome sequence; and developed an infectious r...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1002/hep.29494
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Authors
Funding
Bibliographic Details
- Publisher:
- American Association for the Study of Liver Disease Publisher's website
- Journal:
- Hepatology Journal website
- Volume:
- 60
- Issue:
- 2
- Pages:
- 435-448
- Publication date:
- 2017-08-31
- Acceptance date:
- 2017-08-27
- DOI:
- EISSN:
-
1527-3350
- ISSN:
-
0270-9139
- Pubs id:
-
pubs:724992
- URN:
-
uri:0267b574-510f-4743-b9dd-2d67136e0516
- UUID:
-
uuid:0267b574-510f-4743-b9dd-2d67136e0516
- Local pid:
- pubs:724992
Item Description
Terms of use
- Copyright holder:
- AASLD
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 by the American Association for the Study of Liver Diseases
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