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An antisense RNA capable of modulating the expression of the tumor suppressor microRNA-34a

Abstract:

The microRNA-34a is a well-studied tumor suppressor microRNA (miRNA) and a direct downstream target of TP53 with roles in several pathways associated with oncogenesis, such as proliferation, cellular growth, and differentiation. Due to its broad tumor suppressive activity, it is not surprising that miR34a expression is altered in a wide variety of solid tumors and hematological malignancies. However, the mechanisms by which miR34a is regulated in these cancers is largely unknown. In this stud...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41419-018-0777-5

Authors


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ORCID:
0000-0002-5778-7014
Andrews, N More by this author
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ORCID:
0000-0003-0002-5614
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Oxford college:
St Hildas
ORCID:
0000-0002-3415-3449
Houtman, M More by this author
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Publisher:
Springer Nature Publisher's website
Journal:
Cell Death and Disease Journal website
Volume:
9
Issue:
7
Pages:
Article: 736
Publication date:
2018-07-03
Acceptance date:
2018-05-31
DOI:
ISSN:
2041-4889
Pubs id:
pubs:892749
URN:
uri:025ca355-bec3-48c3-ab19-341f2352effa
UUID:
uuid:025ca355-bec3-48c3-ab19-341f2352effa
Local pid:
pubs:892749
Language:
English

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