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An antisense RNA capable of modulating the expression of the tumor suppressor microRNA-34a

Abstract:

The microRNA-34a is a well-studied tumor suppressor microRNA (miRNA) and a direct downstream target of TP53 with roles in several pathways associated with oncogenesis, such as proliferation, cellular growth, and differentiation. Due to its broad tumor suppressive activity, it is not surprising that miR34a expression is altered in a wide variety of solid tumors and hematological malignancies. However, the mechanisms by which miR34a is regulated in these cancers is largely unknown. In this stud...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41419-018-0777-5

Authors


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Role:
Author
ORCID:
0000-0002-5778-7014
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Role:
Author
ORCID:
0000-0003-0002-5614
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Oxford college:
St Hilda's College
Role:
Author
ORCID:
0000-0002-3415-3449
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Publisher:
Springer Nature Publisher's website
Journal:
Cell Death and Disease Journal website
Volume:
9
Issue:
7
Article number:
736
Publication date:
2018-07-03
Acceptance date:
2018-05-31
DOI:
ISSN:
2041-4889
Pmid:
29970884
Source identifiers:
892749
Language:
English
Pubs id:
pubs:892749
UUID:
uuid:025ca355-bec3-48c3-ab19-341f2352effa
Local pid:
pubs:892749
Deposit date:
2018-08-07

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