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Mycolactone-mediated neurite degeneration and functional effects in cultured human and rat DRG neurons: mechanisms underlying hypoalgesia in Buruli ulcer

Abstract:
Background Mycolactone is a polyketide toxin secreted by the mycobacterium Mycobacterium ulcerans, responsible for the extensive hypoalgesic skin lesions characteristic of patients with Buruli ulcer. A recent pre-clinical study proposed that mycolactone may produce analgesia via activation of the angiotensin II type 2 receptor (AT2R). In contrast, AT2R antagonist EMA401 has shown analgesic efficacy in animal models and clinical trials for neuropathic pain. We therefore invest... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1177/1744806916654144

Authors


Macquillan, A More by this author
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Spinifex Pharmaceuticals, Inc. More from this funder
Publisher:
SAGE Publisher's website
Journal:
Molecular Pain Journal website
Volume:
12
Pages:
Article: 174480691665414
Publication date:
2016-06-20
Acceptance date:
2016-05-16
DOI:
ISSN:
1744-8069
Pubs id:
pubs:631402
URN:
uri:024f6207-6d92-416f-ba2e-2ec8b92ae631
UUID:
uuid:024f6207-6d92-416f-ba2e-2ec8b92ae631
Local pid:
pubs:631402

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