Journal article
Mycolactone-mediated neurite degeneration and functional effects in cultured human and rat DRG neurons: mechanisms underlying hypoalgesia in Buruli ulcer
- Abstract:
-
Background Mycolactone is a polyketide toxin secreted by the mycobacterium Mycobacterium ulcerans, responsible for the extensive hypoalgesic skin lesions characteristic of patients with Buruli ulcer. A recent pre-clinical study proposed that mycolactone may produce analgesia via activation of the angiotensin II type 2 receptor (AT2R). In contrast, AT2R antagonist EMA401 has shown analgesic efficacy in animal models and clinical trials for neuropathic pain. We therefore invest... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Spinifex Pharmaceuticals, Inc.
More from this funder
Bibliographic Details
- Publisher:
- SAGE Publications Publisher's website
- Journal:
- Molecular Pain Journal website
- Volume:
- 12
- Article number:
- 174480691665414
- Publication date:
- 2016-06-20
- Acceptance date:
- 2016-05-16
- DOI:
- ISSN:
-
1744-8069
- Pmid:
-
27325560
- Source identifiers:
-
631402
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:631402
- UUID:
-
uuid:024f6207-6d92-416f-ba2e-2ec8b92ae631
- Local pid:
- pubs:631402
- Deposit date:
- 2018-07-24
Terms of use
- Copyright holder:
- Anand et al
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 The Authors. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
- Licence:
- Other
If you are the owner of this record, you can report an update to it here: Report update to this record