- Abstract:
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Background Mycolactone is a polyketide toxin secreted by the mycobacterium Mycobacterium ulcerans, responsible for the extensive hypoalgesic skin lesions characteristic of patients with Buruli ulcer. A recent pre-clinical study proposed that mycolactone may produce analgesia via activation of the angiotensin II type 2 receptor (AT2R). In contrast, AT2R antagonist EMA401 has shown analgesic efficacy in animal models and clinical trials for neuropathic pain. We therefore invest... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 1.4mb)
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- Publisher copy:
- 10.1177/1744806916654144
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- Publisher:
- SAGE Publisher's website
- Journal:
- Molecular Pain Journal website
- Volume:
- 12
- Pages:
- Article: 174480691665414
- Publication date:
- 2016-06-20
- Acceptance date:
- 2016-05-16
- DOI:
- ISSN:
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1744-8069
- Pubs id:
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pubs:631402
- URN:
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uri:024f6207-6d92-416f-ba2e-2ec8b92ae631
- UUID:
-
uuid:024f6207-6d92-416f-ba2e-2ec8b92ae631
- Local pid:
- pubs:631402
- Language:
- English
- Keywords:
- Copyright holder:
- Anand et al.
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 The Authors. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Journal article
Mycolactone-mediated neurite degeneration and functional effects in cultured human and rat DRG neurons: mechanisms underlying hypoalgesia in Buruli ulcer
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Spinifex Pharmaceuticals, Inc.
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