Thesis
The structural and cellular biology of endogenous TLR4 activators in inflammatory disease
- Abstract:
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Toll-like receptors (TLRs) are critical to detecting the presence of dangerous infections, initiating a protective innate immune response, and triggering a long-lasting adaptive immune response. TLRs initiate defensive, pro inflammatory signalling following direct binding to pathogen-associated molecular patterns (PAMPs), which are exogenous molecular fingerprints derived from infectious pathogens like bacteria, viruses, and fungi. In addition to this role, more recent evidence demonstrates t...
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(Preview, Dissemination version, pdf, 37.6MB, Terms of use)
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(Supplementary materials, xlsx, 366.5KB, Terms of use)
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(Supplementary materials, xlsx, 1.9MB, Terms of use)
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(Supplementary materials, xlsx, 18.9KB, Terms of use)
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Authors
Funding
+ Nuffield Department of Medicine
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Programme:
Nuffield Department of Medicine Prize Studentship
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
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English
- Deposit date:
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2021-09-27
Terms of use
- Copyright holder:
- Coker, J
- Copyright date:
- 2021
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