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Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses

Abstract:

A missense C1858T single nucleotide polymorphism within PTPN22 is a strong genetic risk factor for the development of multiple autoimmune diseases. PTPN22 encodes a protein tyrosine phosphatase that negatively regulates immuno-receptor proximal Src and Syk family kinases. Notably, PTPN22 negatively regulates kinases downstream of T-cell receptor (TCR) and LFA-1, thereby setting thresholds for T-cell activation. Alterations to the quality of TCR and LFA-1 engagement at the immune synapse and t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.jaut.2018.07.008

Authors


Sanchez-Blanco, C More by this author
Cornish, GH More by this author
Thompson, SJ More by this author
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Grant:
202911/Z/16/Z
100262/Z/12/Z
Children's Guild Association More from this funder
Benaroya Family Gift Fund More from this funder
National Institute for Health Research More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Journal of Autoimmunity Journal website
Volume:
94
Issue:
November 2018
Pages:
45-55
Publication date:
2018-07-24
Acceptance date:
2018-07-13
DOI:
EISSN:
1095-9157
ISSN:
0896-8411
Pubs id:
pubs:890247
URN:
uri:0224bb33-4190-4b4b-8495-a35d7b1afdbe
UUID:
uuid:0224bb33-4190-4b4b-8495-a35d7b1afdbe
Local pid:
pubs:890247

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