- Abstract:
-
A missense C1858T single nucleotide polymorphism within PTPN22 is a strong genetic risk factor for the development of multiple autoimmune diseases. PTPN22 encodes a protein tyrosine phosphatase that negatively regulates immuno-receptor proximal Src and Syk family kinases. Notably, PTPN22 negatively regulates kinases downstream of T-cell receptor (TCR) and LFA-1, thereby setting thresholds for T-cell activation. Alterations to the quality of TCR and LFA-1 engagement at the immune synapse and t...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.7mb)
-
(pdf, 1.7mb)
-
- Publisher copy:
- 10.1016/j.jaut.2018.07.008
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Journal of Autoimmunity Journal website
- Volume:
- 94
- Issue:
- November 2018
- Pages:
- 45-55
- Publication date:
- 2018-07-24
- Acceptance date:
- 2018-07-13
- DOI:
- EISSN:
-
1095-9157
- ISSN:
-
0896-8411
- Pubs id:
-
pubs:890247
- URN:
-
uri:0224bb33-4190-4b4b-8495-a35d7b1afdbe
- UUID:
-
uuid:0224bb33-4190-4b4b-8495-a35d7b1afdbe
- Local pid:
- pubs:890247
- Language:
- English
- Keywords:
- Copyright holder:
- Sanchez-Blanco, C al.
- Copyright date:
- 2018
- Notes:
- © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license.
Journal article
Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses
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Children's Guild Association
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National Institute for Health Research
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