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SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes

Abstract:

BACKGROUND: Genome-wide association studies (GWAS) of single nucleotide polymorphisms (SNPs) have been successful in identifying loci contributing genetic effects to a wide range of complex human diseases and quantitative traits. The traditional approach to GWAS analysis is to consider each phenotype separately, despite the fact that many diseases and quantitative traits are correlated with each other, and often measured in the same sample of individuals. Multivariate analyses of correlated p...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12859-016-1437-3

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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
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Funding agency for:
Morris, AP
Publisher:
BioMed Central Publisher's website
Journal:
BMC Bioinformatics Journal website
Volume:
18
Issue:
1
Pages:
Article: 25
Publication date:
2017-01-11
DOI:
ISSN:
1471-2105
Pubs id:
pubs:671739
URN:
uri:021d0f77-7fef-4216-a704-99f560f3a09c
UUID:
uuid:021d0f77-7fef-4216-a704-99f560f3a09c
Local pid:
pubs:671739
Paper number:
1

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