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The ambiguity of brain metastasis response to radiotherapy driven by cellular adhesion molecules

Abstract:

Brain metastases treatments are usually based on surgery and radiation therapies with poor patient survival. Cellular adhesion molecules (CAMs) are promiscuous proteins highly involved in tumour progression. Owing to their dual functionality in structure and signalling, CAMs have emerged as potential targets in the clinic. It has been shown that CAMs can modulate radiation response in different types of tumours, triggering either apoptosis or resistance. However, this complex behaviour has no...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1093/neuonc/nox036.385

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Subgroup:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Subgroup:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
ORCID:
0000-0002-4169-8447
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Subgroup:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
ORCID:
0000-0003-1211-2766
Publisher:
Oxford University Press Publisher's website
Volume:
19
Pages:
101
Publication date:
2017-04-19
DOI:
EISSN:
1523-5866
ISSN:
1522-8517
Pubs id:
pubs:719632
URN:
uri:01f9b7d0-a5db-4023-ba24-25c5e922dcb6
UUID:
uuid:01f9b7d0-a5db-4023-ba24-25c5e922dcb6
Local pid:
pubs:719632

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