Cytophilic properties of surface immunoglobulin of thymus-derived lymphocytes.

Journal article

The cytophilic properties of released surface immunoglobulins of normal thymus lymphocytes and of activated thymus derived lymphocytes (ATC) were analysed by lactoperoxidase catalysed radioiodination in conjunction with immunological and autoradiographic techniques. Immunoglobulin from both normal T cells and ATC was cytophilic for macrophages (peritoneal exudate cells), but showed no detectable capacity to bind to either T lymphocytes or to bone marrow derived lymphocytes (B cells). Under the operative experimental conditions, surface immunoglobulin of B cells did not show appreciable binding to macrophages. These results support the feasibility of models of collaboration between T cells and B cells which involve a soluble antigen specific collaborative factor (T cell Ig complexed with antigen) and show an obligatory requirement for macrophages.

Authors: Cone, R; Feldmann, M; Marchalonis, J; Nossal, G

• Journal: Immunology
• Volume: 26
• Issue: 1
• Pages: 49-60
• Publication date: 1974-01-01
• EISSN: 1365-2567
• ISSN: 0019-2805
• Language: English
• Keywords: Sheep; Immunity, Cellular; Ascitic Fluid; Immunoglobulin M; Immunoglobulins; Animals; Erythrocytes; Mice; T-Lymphocytes; Binding Sites, Antibody; Autoradiography; Iodine Radioisotopes; B-Lymphocytes; Electrophoresis, Polyacrylamide Gel; Cell Membrane; Macrophages