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Variant surface glycoprotein synthesis and cell cycle progression in Trypanosoma brucei

Abstract:

The unicellular eukaryote Trypanosoma brucei causes African Sleeping sickness and multiplies extracellularly in the bloodstream of the infected host. The parasite evades antibody-mediated lysis by switching its Variant Surface Glycoprotein (VSG) coat. Blocking VSG synthesis results in an abrupt growth inhibition and a precise pre-cytokinesis cell cycle arrest, with an accumulation of cells with two nuclei and two kinetoplasts. Additionally, induction of VSG RNAi ...

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Institution:
University of Oxford
Oxford college:
Somerville College
Department:
Medical Sciences Division - Biochemistry
Role:
Author

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Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:01bbdf34-8cb3-4942-a14d-d6ba3a3e669d
Local pid:
ora:12138

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