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Thesis

The safety, tolerability and biochemical efficacy of extended release niacin and laropiprant in a major randomised clinical trial

Abstract:

Niacin has been in clinical use for over 50 years and was the first drug shown in a randomized trial to improve outcomes after MI, but substantial uncertainty remains about its efficacy and safety in the context of current standard medical therapy.

This thesis explores the biochemical efficacy, tolerability and safety of extended release (ER) niacin/laropiprant in the large, randomized HPS2-THRIVE trial. Laropiprant is a prostaglandin D₂ receptor (DP1) antagonist which reduces the ma...

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Institution:
University of Oxford
Oxford college:
Magdalen College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Clinical Trial Service Unit

Contributors

Role:
Supervisor
Publication date:
2013
Type of award:
DM
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:01ba360a-fe6a-4a1a-ba14-48a2dcc3e0dd
Local pid:
ora:8768
Language:
English
Keywords:
Subjects:

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