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Pulsatile insulin has greater hypoglycemic effect than continuous delivery.

Abstract:

The relative hypoglycemic effects of pulsatile versus steadily infused insulin have been examined in six normal subjects in whom pancreatic insulin output was suppressed by somatostatin-14. Soluble insulin was infused continuously overnight on one occasion and on another occasion the same quantity was given in pulses of 2-min duration with a gap of 11 min. The mean plasma glucose concentrations were lower when pulsed insulin was given [mean for the last hour: 4.66 +/- 0.08 mmol/L (+/- SEM) ve...

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Publication status:
Published

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Publisher copy:
10.2337/diab.32.7.617

Authors


Matthews, DR More by this author
Naylor, BA More by this author
Turner, RC More by this author
Journal:
Diabetes
Volume:
32
Issue:
7
Pages:
617-621
Publication date:
1983-07-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:0189cbb3-06b0-436a-988c-6932801b4002
Source identifiers:
72926
Local pid:
pubs:72926

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