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Genetic cardiomyopathies causing heart failure.

Abstract:

Despite the striking advances in medical and surgical therapy, the morbidity, mortality, and economic burden of heart failure (HF) remain unacceptably high. There is increasing evidence that the risk and course of HF depend on genetic predisposition; however, the genetic contribution to HF is heterogeneous and complex. At one end of the spectrum are the familial monogenic HF syndromes in which causative mutations are rare but highly penetrant. At the other, HF susceptibility and course may be...

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Publication status:
Published

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Authors


Cahill, TJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Watkins, H More by this author
Journal:
Circulation research
Volume:
113
Issue:
6
Pages:
660-675
Publication date:
2013-08-05
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
URN:
uuid:018314f6-af93-4117-97d1-d189b63d4a37
Source identifiers:
420622
Local pid:
pubs:420622

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