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Trophoblast deportation and the maternal inflammatory response in pre-eclampsia.

Abstract:

We have proposed that the maternal syndrome of pre-eclampsia is caused by a systemic inflammatory response involving both leucocytes and endothelium. This inflammatory response is present also in normal pregnancy, but in a milder form. The inflammatory stimulus is most likely to come from the placenta. Syncytiotrophoblast apoptotic debris, which is shed into the maternal circulation in normal pregnancy and in increased amounts in pre-eclampsia, may be the stimulus for this response. It may al...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Role:
Author
Journal:
Journal of reproductive immunology
Volume:
59
Issue:
2
Pages:
153-160
Publication date:
2003-08-05
DOI:
EISSN:
1872-7603
ISSN:
0165-0378
URN:
uuid:017cae19-3854-48a8-ab9b-51a23260f79e
Source identifiers:
248190
Local pid:
pubs:248190

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