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Journal article

Searching for archaic contribution in Africa

Abstract:

Context: Africa’s role in the narrative of human evolution is indisputably emphasised in the emergence Homo sapiens. However, once humans disperse beyond Africa, the history of those who stayed remains vastly understudied lacking the proper attention it deserves as the birthplace of both modern and archaic humans. The sequencing of Neanderthal and Denisovan genomes has elucidated evidence of admixture between archaic and modern humans outside of Africa but has not aided efforts in answering whether archaic admixture happened within Africa.

Objectives: We review here the state of research for archaic introgression in African populations and discuss recent insights into this topic.

Methods: Gathering published sources and recently released preprints, this review reports on the different methods developed for detecting archaic introgression. Particularly we discuss how relevant these are when implemented on African populations and what findings these studies have shown so far.

Results: Methods for detecting archaic introgression have been predominantly developed and implemented on non-African populations. Recent preprints present new methods considering African populations. While a number of studies using these methods suggest archaic introgression in Africa, without an African archaic genome to validate these results, such findings remain as putative archaic introgression.

Conclusion: In light of the caveats with implementing current archaic introgression detection methods in Africa, we recommend future studies to concentrate on unravelling the complicated demographic history of Africa through means of ancient DNA where possible and through more focused efforts to sequence modern DNA from more representative populations across the African continent.

Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1080/03014460.2019.1624823

Authors


More by this author
Institution:
University of Oxford
Department:
Zoology
Role:
Author
ORCID:
0000-0003-3021-6809
More by this author
Institution:
University of Oxford
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Oxford college:
St Hugh's College
Role:
Author
ORCID:
0000-0001-9348-9084


Publisher:
Taylor and Francis
Journal:
Annals of Human Biology More from this journal
Volume:
46
Issue:
2
Pages:
129-139
Publication date:
2019-06-04
Acceptance date:
2019-05-17
DOI:
EISSN:
1464-5033
ISSN:
0301-4460
Pmid:
31163991


Language:
English
Keywords:
Pubs id:
pubs:1012938
UUID:
uuid:017abb50-6771-4d1b-91fc-974afa63b664
Local pid:
pubs:1012938
Source identifiers:
1012938
Deposit date:
2019-06-24

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