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From genetic association to molecular mechanism.

Abstract:

Over the past 3 years, there has been a dramatic increase in the number of confirmed type 2 diabetes (T2D) susceptibility loci, most arising through the implementation of genome-wide association studies (GWAS). However, progress toward the understanding of disease mechanisms has been slowed by modest effect sizes and the fact that most GWAS signals map away from coding sequence: the presumption is that their effects are mediated through regulation of nearby transcripts, but the identities of ...

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Publisher copy:
10.1007/s11892-010-0150-2

Authors


van de Bunt, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
Current diabetes reports
Volume:
10
Issue:
6
Pages:
452-466
Publication date:
2010-12-05
DOI:
EISSN:
1539-0829
ISSN:
1534-4827
URN:
uuid:016f1fd8-bb6a-4c48-be0f-616ed22016e3
Source identifiers:
83820
Local pid:
pubs:83820

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