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Prebiotic reduction of brain histone deacetylase (HDAC) activity and olanzapine-mediated weight gain in rats, are acetate independent

Abstract:

The intestinal microbiome is emerging as a novel therapeutic target owing to the wide range of potential health benefits that could result by manipulating the microbiota composition through relatively simple interventions. Ingestion of the prebiotic Bimuno™ galacto-oligosaccharide (B-GOS®) is one such intervention that has been shown to attenuate olanzapine-induced weight gain and improve cognitive flexibility in rats, potentially through mechanisms involving acetate, the major short-chain fa...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Neuropharmacology Journal website
Volume:
150
Pages:
184-191
Publication date:
2019-02-11
Acceptance date:
2019-02-10
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
Pubs id:
pubs:969952
UUID:
uuid:016d6613-e86e-4ebc-91e2-547f15c05112
Source identifiers:
969952
Local pid:
pubs:969952

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