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Journal article

Marker selection for genetic case-control association studies.

Abstract:

Association studies can focus on candidate gene(s), a particular genomic region, or adopt a genome-wide association approach, each of which has implications for marker selection. The strategy for marker selection will affect the statistical power of the study to detect a disease association and is a crucial element of study design. The abundant single nucleotide polymorphisms (SNPs) are the markers of choice in genetic case-control association studies. The genotypes of neighboring SNPs are of...

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Publication status:
Published

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Publisher copy:
10.1038/nprot.2009.38

Authors


Pettersson, FH More by this author
Anderson, CA More by this author
Clarke, GM More by this author
Barrett, JC More by this author
Cardon, LR More by this author
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Journal:
Nature protocols
Volume:
4
Issue:
5
Pages:
743-752
Publication date:
2009
DOI:
EISSN:
1750-2799
ISSN:
1754-2189
URN:
uuid:0166a589-992f-47be-bfc1-43628aa07f7c
Source identifiers:
34699
Local pid:
pubs:34699

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