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Rescue of biosynthesis of nicotinamide adenine dinucleotide protects the heart in cardiomyopathy caused by lamin A/C gene mutation

Abstract:

Cardiomyopathy caused by lamin A/C gene (LMNA) mutations (hereafter referred as LMNA cardiomyopathy) is an anatomic and pathologic condition associated with muscle and electrical dysfunction of the heart, often leading to heart failure-related disability. There is currently no specific therapy available for patients that target the molecular pathophysiology of LMNA cardiomyopathy. Recent studies suggested that nicotinamide adenine dinucleotide (NAD+) cellular content could be a critical deter...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/hmg/ddy278

Authors


Vignier, N More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Subgroup:
CRUK/MRC Ox Inst Radiation Oncology
Morales Rodriguez, B More by this author
Mericskay, M More by this author
Mougenot, N More by this author
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Publisher:
Oxford University Press Publisher's website
Journal:
Human Molecular Genetics Journal website
Volume:
27
Issue:
22
Pages:
3870-3880
Publication date:
2018-07-24
Acceptance date:
2018-07-20
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Pubs id:
pubs:943862
URN:
uri:01653052-2b44-42f7-89b6-ffffa11f2510
UUID:
uuid:01653052-2b44-42f7-89b6-ffffa11f2510
Local pid:
pubs:943862

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