Elementary steps in T cell receptor triggering.

Journal article

The mechanism by which antigen binding to the T cell antigen receptor (TCR) generates intracellular signaling, a process termed TCR triggering, is incompletely understood. A large body of experimental evidence has implicated multiple biophysical/biochemical effects and multiple molecules in the process of TCR triggering, which likely reflect the uniquely demanding role of the TCR in recognizing diverse antigenic ligands. In this perspective, I propose that breaking down the process of TCR triggering into tractable elementary steps may be a useful approach in building mechanistic TCR triggering models. Once these elementary steps are understood, they can be recombined to build a unified model of TCR triggering.

Authors: Dushek, O

• Journal: Frontiers in immunology
• Volume: 2
• Issue: JAN
• Pages: 91
• Publication date: 2011-01-01
• DOI: 10.3389/fimmu.2011.00091
• EISSN: 1664-3224
• Language: English
• Keywords: T cell receptor; mathematical model; kinase-phosphatase cycles; T cell activation; receptor triggering