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Elementary steps in T cell receptor triggering.

Abstract:

The mechanism by which antigen binding to the T cell antigen receptor (TCR) generates intracellular signaling, a process termed TCR triggering, is incompletely understood. A large body of experimental evidence has implicated multiple biophysical/biochemical effects and multiple molecules in the process of TCR triggering, which likely reflect the uniquely demanding role of the TCR in recognizing diverse antigenic ligands. In this perspective, I propose that breaking down the process of TCR tri...

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Publisher copy:
10.3389/fimmu.2011.00091

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Frontiers in immunology
Volume:
2
Issue:
JAN
Pages:
91
Publication date:
2011
DOI:
EISSN:
1664-3224
URN:
uuid:01640666-ec45-4066-ad3b-2537d7047fd1
Source identifiers:
332859
Local pid:
pubs:332859

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