The mechanism by which antigen binding to the T cell antigen receptor (TCR) generates intracellular signaling, a process termed TCR triggering, is incompletely understood. A large body of experimental evidence has implicated multiple biophysical/biochemical effects and multiple molecules in the process of TCR triggering, which likely reflect the uniquely demanding role of the TCR in recognizing diverse antigenic ligands. In this perspective, I propose that breaking down the process of TCR tri...Expand abstract
- Publisher copy:
- Copyright date:
Elementary steps in T cell receptor triggering.
If you are the owner of this record, you can report an update to it here: Report update to this record