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Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase.

Abstract:

Sulfonamides were amongst the first clinically useful antibacterial agents to be discovered. The identification of sulfanilamide as the active component of the dye Prontosil rubrum led to the synthesis of clinically useful analogues. Today sulfamethoxazole (in combination with trimethoprim), is used to treat urinary tract infections caused by bacteria such as Escherichia coli and is also a first-line treatment for pneumonia caused by the fungus Pneumocystis carinii, a common condition in AIDS...

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Publication status:
Published

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Publisher copy:
10.1038/nsb0697-490

Authors


Somers, DO More by this author
Champness, JN More by this author
Bryant, PK More by this author
Rosemond, J More by this author
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Journal:
Nature structural biology
Volume:
4
Issue:
6
Pages:
490-497
Publication date:
1997-06-05
DOI:
ISSN:
1072-8368
URN:
uuid:0158a715-b016-4b8e-8759-46c699aeb291
Source identifiers:
72683
Local pid:
pubs:72683

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