Journal article icon

Journal article

Investigating the genetic relationship between Alzheimer’s disease and cancer using GWAS summary statistics

Abstract:

Growing evidence from both epidemiology and basic science suggest an inverse association between Alzheimer’s disease (AD) and cancer. We examined the genetic relationship between AD and various cancer types using GWAS summary statistics from the IGAP and GAME-ON consortia. Sample size ranged from 9931 to 54,162; SNPs were imputed to the 1000 Genomes European panel. Our results based on cross-trait LD Score regression showed a significant positive genetic correlation between AD and five cancer...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

Actions


Access Document


Files:
Publisher copy:
10.1007/s00439-017-1831-6

Authors


Feng, Y-CA More by this author
Lindstrom, S More by this author
Cormack, J More by this author
Expand authors...
French National Institute of Health and Medical Research More from this funder
German Federal Ministry of Education and Research More from this funder
Expand funders...
Publisher:
Springer Publisher's website
Journal:
Human Genetics Journal website
Volume:
136
Issue:
10
Pages:
1341-1351
Publication date:
2017-08-05
Acceptance date:
2017-06-01
DOI:
EISSN:
1432-1203
ISSN:
0340-6717
Pubs id:
pubs:721440
URN:
uri:014e7ecb-82d0-4756-854e-bc108c55833f
UUID:
uuid:014e7ecb-82d0-4756-854e-bc108c55833f
Local pid:
pubs:721440
Keywords:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP