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Journal article

Label-free, all-optical detection, imaging, and tracking of a single protein.

Abstract:

Optical detection of individual proteins requires fluorescent labeling. Cavity and plasmonic methodologies enhance single molecule signatures in the absence of any labels but have struggled to demonstrate routine and quantitative single protein detection. Here, we used interferometric scattering microscopy not only to detect but also to image and nanometrically track the motion of single myosin 5a heavy meromyosin molecules without the use of labels or any nanoscopic amplification. Together w...

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Publication status:
Published

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Publisher copy:
10.1021/nl500234t

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Publisher:
American Chemical Society
Journal:
Nano letters
Volume:
14
Issue:
4
Pages:
2065-2070
Publication date:
2014-01-01
DOI:
EISSN:
1530-6992
ISSN:
1530-6984
URN:
uuid:0142cb70-3001-4b3a-9def-dfceeddc5176
Source identifiers:
451161
Local pid:
pubs:451161

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