Journal article
Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease.
- Abstract:
-
The memory dysfunction of Alzheimer disease has been associated with a cortical cholinergic deficiency and loss of cholinergic neurons of the nucleus basalis of Meynert. This cholinergic component of Alzheimer disease can be modeled in the rat by ibotenic acid lesions of the cholinergic nucleus basalis magnocellularis. The memory impairment caused by such unilateral lesions, as reflected in passive avoidance behavior, is reversed by grafts into the deafferented neocortex of embryonic neurons ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1073/pnas.82.15.5227
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Bibliographic Details
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 82
- Issue:
- 15
- Pages:
- 5227-5230
- Publication date:
- 1985-08-01
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- Source identifiers:
-
15401
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:15401
- UUID:
-
uuid:0142c224-b361-41a0-8916-689e5064cdb4
- Local pid:
- pubs:15401
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1985
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