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Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease.

Abstract:

The memory dysfunction of Alzheimer disease has been associated with a cortical cholinergic deficiency and loss of cholinergic neurons of the nucleus basalis of Meynert. This cholinergic component of Alzheimer disease can be modeled in the rat by ibotenic acid lesions of the cholinergic nucleus basalis magnocellularis. The memory impairment caused by such unilateral lesions, as reflected in passive avoidance behavior, is reversed by grafts into the deafferented neocortex of embryonic neurons ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.82.15.5227

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
82
Issue:
15
Pages:
5227-5230
Publication date:
1985-08-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:0142c224-b361-41a0-8916-689e5064cdb4
Source identifiers:
15401
Local pid:
pubs:15401

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