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The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project

Abstract:

BACKGROUND: The loss of noradrenergic neurones of the locus coeruleus is a major feature of Alzheimer's disease (AD). Dopamine β-hydroxylase (DBH) catalyses the conversion of dopamine to noradrenaline. Interactions have been reported between the low-activity -1021T allele (rs1611115) of DBH and polymorphisms of the pro-inflammatory cytokine genes, IL1A and IL6, contributing to the risk of AD. We therefore examined the associations with AD of the DBH -1021T allele and of the above interaction...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1186/1471-2350-11-162

Authors


Combarros, O More by this author
Warden, DR More by this author
Hammond, N More by this author
Cortina-Borja, M More by this author
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Department:
Oxford, MSD, Pharmacology
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Publisher:
BioMed Central Publisher's website
Journal:
BMC medical genetics Journal website
Volume:
11
Issue:
1
Pages:
162
Publication date:
2010-11-11
DOI:
EISSN:
1471-2350
Pubs id:
pubs:107151
URN:
uri:013009c4-c08e-415c-87aa-4be3e41afaf4
UUID:
uuid:013009c4-c08e-415c-87aa-4be3e41afaf4
Local pid:
pubs:107151
Language:
English
Keywords:

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