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Field- and clinically derived estimates of Wolbachia-mediated blocking of dengue virus transmission potential in Aedes aegypti mosquitoes.

Abstract:

The wMel strain of Wolbachia can reduce the permissiveness of Aedes aegypti mosquitoes to disseminated arboviral infections. Here, we report that wMel-infected Ae. aegypti (Ho Chi Minh City background), when directly blood-fed on 141 viremic dengue patients, have lower dengue virus (DENV) transmission potential and have a longer extrinsic incubation period than their wild-type counterparts. The wMel-infected mosquitoes that are field-reared have even greater relative resistance to DENV infect...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1073/pnas.1715788115

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Role:
Author
ORCID:
0000-0001-9273-7912
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Wellcome Trust More from this funder
Australian National Health and Medical Research Council More from this funder
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
115
Issue:
2
Pages:
361-366
Publication date:
2018-01-05
Acceptance date:
2017-11-29
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:813185
URN:
uri:010a33bd-07fa-4b3a-9389-99ff21e49543
UUID:
uuid:010a33bd-07fa-4b3a-9389-99ff21e49543
Local pid:
pubs:813185

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