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Journal article

Microcephaly proteins Wdr62 and Aspm define a mother centriole complex regulating centriole biogenesis, apical complex, and cell fate

Abstract:

Mutations in several genes encoding centrosomal proteins dramatically decrease the size of the human brain. We show that Aspm (abnormal spindle-like, microcephaly-associated) and Wdr62 (WD repeat-containing protein 62) interact genetically to control brain size, with mice lacking Wdr62, Aspm, or both showing gene dose-related centriole duplication defects that parallel the severity of the microcephaly and increased ectopic basal progenitors, suggesting premature delamination from the ventricu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Wellcome Trust More from this funder
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Grant:
R01 NS032457; R01 NS035129; R21 NS091865; T32 NS007484; R21 NS091865-01
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Publisher:
Cell Press Publisher's website
Journal:
Neuron Journal website
Volume:
92
Issue:
4
Pages:
813-828
Publication date:
2016-11-05
Acceptance date:
2016-09-19
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
Pubs id:
pubs:664202
URN:
uri:00dadbb7-8c28-4938-a06e-3212da637a0f
UUID:
uuid:00dadbb7-8c28-4938-a06e-3212da637a0f
Local pid:
pubs:664202
Paper number:
4

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