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Comparative pan-genomic analyses of Orientia tsutsugamushi reveal an exceptional model of bacterial evolution driving genomic diversity

Abstract:

Orientia tsutsugamushi, formerly Rickettsia tsutsugamushi, is an obligate intracellular pathogen that causes scrub typhus, an underdiagnosed acute febrile disease with high morbidity. Scrub typhus is transmitted by the larval stage (chigger) of Leptotrombidium mites and is irregularly distributed across endemic regions of Asia, Australia and islands of the western Pacific Ocean. Previous work to understand population genetics in O. tsutsugamushi has been based on sub-genomic sampling methods ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1099/mgen.0.000199

Authors


Fleshman, A More by this author
Mullins, K More by this author
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USA Armed Forces Health Surveillance Branch More from this funder
Global Emerging Infections Surveillance and Response Systems More from this funder
Wellcome Trust More from this funder
Publisher:
Microbiology Society Publisher's website
Journal:
Microbial Genomics Journal website
Volume:
4
Issue:
9
Publication date:
2018-07-23
Acceptance date:
2018-06-26
DOI:
EISSN:
2057-5858
Pubs id:
pubs:891351
URN:
uri:00c58c60-2708-4f51-89ee-0add4e79bb04
UUID:
uuid:00c58c60-2708-4f51-89ee-0add4e79bb04
Local pid:
pubs:891351

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