Thesis
Kinetic resolution in rhodium-catalyzed [5+2] cycloisomerization
- Abstract:
-
This thesis demonstrates the ability of a rhodium(I)-phosphoramidite catalyst to effect the first examples of kinetic resolution in [5+2] cycloisomerization (Scheme i). This methodology was applied to a range of diversely substituted enyne substrates, including a novel chiral silane tether. Depending on the substrate, either a classical resolution, or a diastereodivergent resolution was achieved, both with exceptional selectivity.
Furthermore, this methodology was applied to the as...
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Subjects:
- Deposit date:
- 2021-01-11
Related Items
Terms of use
- Copyright holder:
- Ma, K
- Copyright date:
- 2020
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