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Thesis

Kinetic resolution in rhodium-catalyzed [5+2] cycloisomerization

Abstract:

This thesis demonstrates the ability of a rhodium(I)-phosphoramidite catalyst to effect the first examples of kinetic resolution in [5+2] cycloisomerization (Scheme i). This methodology was applied to a range of diversely substituted enyne substrates, including a novel chiral silane tether. Depending on the substrate, either a classical resolution, or a diastereodivergent resolution was achieved, both with exceptional selectivity.

Furthermore, this methodology was applied to the as...

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Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Subjects:
Deposit date:
2021-01-11

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