Journal article
Exploring PAZ/3′-overhang interaction to improve siRNA specificity: a combined experimental and modeling study
- Abstract:
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The understanding of the dynamical and mechanistic aspects that lie behind siRNA-based gene regulation is a requisite to boost the performance of siRNA therapeutics. A systematic experimental and computational study on the 3′-overhang structural requirements for the design of more specific and potent siRNA molecules was carried out using nucleotide analogues differing in structural parameters, such as sugar constraint, lack of nucleobase, distance between the phosphodiester backbone and nucle...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Preview, Version of record, pdf, 2.3MB, Terms of use)
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- Publisher copy:
- 10.1039/c8sc00010g
Authors
Funding
+ Ministerio de Ciencia e Innovación
More from this funder
Grant:
CTQ2014-52588-RCTQ2017-84415-R
CTQ2016-78636-P
Bibliographic Details
- Publisher:
- Royal Society of Chemistry
- Journal:
- Chemical Science More from this journal
- Volume:
- 9
- Issue:
- 8
- Pages:
- 2074-2086
- Publication date:
- 2018-01-15
- Acceptance date:
- 2018-01-15
- DOI:
- EISSN:
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2041-6539
- ISSN:
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2041-6520
- Pmid:
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29719684
Item Description
- Language:
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English
- Pubs id:
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pubs:830351
- UUID:
-
uuid:0088e204-5f00-4530-95ce-f8f872624b3d
- Local pid:
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pubs:830351
- Source identifiers:
-
830351
- Deposit date:
-
2018-06-07
Terms of use
- Copyright holder:
- Alagia et al
- Copyright date:
- 2018
- Notes:
- This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
- Licence:
- CC Attribution (CC BY)
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