Journal article icon

Journal article

Exploring PAZ/3′-overhang interaction to improve siRNA specificity: a combined experimental and modeling study

Abstract:

The understanding of the dynamical and mechanistic aspects that lie behind siRNA-based gene regulation is a requisite to boost the performance of siRNA therapeutics. A systematic experimental and computational study on the 3′-overhang structural requirements for the design of more specific and potent siRNA molecules was carried out using nucleotide analogues differing in structural parameters, such as sugar constraint, lack of nucleobase, distance between the phosphodiester backbone and nucle...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1039/c8sc00010g

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
ORCID:
0000-0001-6421-7733
More by this author
ORCID:
0000-0002-9415-7337
More by this author
ORCID:
0000-0003-3047-738X
More by this author
ORCID:
0000-0002-2840-6091
More by this author
ORCID:
0000-0002-6687-382X
Expand authors...
More from this funder
Grant:
CTQ2014-52588-R CTQ2017-84415-R and CTQ2016-78636-P
Generalitat de Catalunya More from this funder
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Chemical Science Journal website
Volume:
9
Issue:
8
Pages:
2074-2086
Publication date:
2018-01-15
Acceptance date:
2018-01-15
DOI:
EISSN:
2041-6539
ISSN:
2041-6520
Pubs id:
pubs:830351
URN:
uri:0088e204-5f00-4530-95ce-f8f872624b3d
UUID:
uuid:0088e204-5f00-4530-95ce-f8f872624b3d
Local pid:
pubs:830351
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP