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Journal article

MARCO variants are associated with phagocytosis, pulmonary tuberculosis susceptibility and Beijing lineage

Abstract:

Macrophage receptor with collagenous structure (MARCO) has an important role in the phagocytosis of Mycobacterium tuberculosis (M. tuberculosis). We hypothesized that MARCO polymorphisms are associated with phagocytosis, tuberculosis (TB) disease susceptibility and presentation, and infecting lineage. We used a human cellular model to examine how MARCO genotype mediates the immune response; a case-control study to investigate tuberculosis host genetic susceptibility; and a host-pathogen genet...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/gene.2016.43

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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Role:
Author
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Grant:
Training Fellowship in Public Health and Tropical Medicine awarded to NTTT (097124/Z/11/Z)
Publisher:
Nature Publishing Group Publisher's website
Journal:
Genes and Immunity Journal website
Volume:
17
Issue:
7
Pages:
419–425
Publication date:
2016-11-17
DOI:
EISSN:
1476-5470
ISSN:
1466-4879
Pubs id:
pubs:660180
URN:
uri:00869f77-49dc-4289-98ba-750db55da256
UUID:
uuid:00869f77-49dc-4289-98ba-750db55da256
Local pid:
pubs:660180
Paper number:
7
Language:
English

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