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Citrullinated human fibrinogen triggers arthritis through an inflammatory response mediated by IL-23/IL-17 immune axis

Abstract:

Rheumatoid arthritis (RA) is an autoimmune disease that causes joint destruction. Although its etiology remains unknown, citrullinated proteins have been considered as an auto-antigen able to trigger an inflammatory response in RA. Herein, we modified the classical antigen-induced arthritis (AIA) model by using citrullinated human plasma fibrinogen (hFIB) as an immunogen to investigate the mechanism of inflammation-driven joint damage by citrullinated hFIB in C57BL/6 mice. We found that hFIB-...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
International Immunopharmacology Journal website
Article number:
108363
Publication date:
2021-11-19
Acceptance date:
2021-11-09
DOI:
ISSN:
1567-5769
Language:
English
Keywords:
Pubs id:
1212019
Local pid:
pubs:1212019
Deposit date:
2021-11-26

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