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Identification of h5n1-specific t-cell responses in a high-risk cohort in Vietnam indicates the existence of potential asymptomatic infections

Abstract:

Background: Most reported human H5N1 viral infections have been severe and were detected after hospital admission. A case ascertainment bias may therefore exist, with mild cases or asymptomatic infections going undetected. We sought evidence of mild or asymptomatic H5N1 infection by examining H5N1-specific T-cell and antibody responses in a high-risk cohort in Vietnam.
Methods: Peripheral blood mononuclear cells were tested using interferon-...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/infdis/jir689

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Subgroup:
Target Discovery Institute
Role:
Author
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077078/Z/05/Z/Wellcome Trust More from this funder
081613/Z/06/Z/Wellcome Trust More from this funder
G0600520/Medical Research Council More from this funder
Medical Research Council More from this funder
G1000800f/Medical Research Council More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
205
Issue:
1
Pages:
20-27
Publication date:
2011-11-11
Acceptance date:
2011-08-09
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Pubs id:
pubs:206077
URN:
uri:0033a61e-3bcd-45e4-8a6f-8d7391ea9cd4
UUID:
uuid:0033a61e-3bcd-45e4-8a6f-8d7391ea9cd4
Local pid:
pubs:206077

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