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Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke

Abstract:
Background and purpose Polymorphisms in coagulation genes have been associated with early-onset ischemic stroke. Here we pursue an a priori hypothesis that genetic variation in the endothelial-based receptors of the thrombomodulin−protein C system (THBD and PROCR) may similarly be associated with early-onset ischemic stroke. We explored this hypothesis utilizing a multi-stage design of discovery and replication.

Methods Discovery was performed in t... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pone.0206554

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ORCID:
0000-0001-9263-8930
Jaworek, T More by this author
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
13
Issue:
11
Pages:
e0206554
Publication date:
2018-11-01
Acceptance date:
2018-10-15
DOI:
EISSN:
1932-6203
Pubs id:
pubs:936707
URN:
uri:001e474a-957b-43fa-a363-3b9577845dba
UUID:
uuid:001e474a-957b-43fa-a363-3b9577845dba
Local pid:
pubs:936707

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