Background and purpose Polymorphisms in coagulation genes have been associated with early-onset ischemic stroke. Here we pursue an a priori hypothesis that genetic variation in the endothelial-based receptors of the thrombomodulin−protein C system (THBD and PROCR) may similarly be associated with early-onset ischemic stroke. We explored this hypothesis utilizing a multi-stage design of discovery and replication.
Methods Discovery was performed in t... Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Publisher's Version
- Public Library of Science Publisher's website
- PloS one Journal website
- Publication date:
- Acceptance date:
- Pubs id:
- Local pid:
- Copyright date:
- This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke
If you are the owner of this record, you can report an update to it here: Report update to this record