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Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial.

Abstract:

BACKGROUND: Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment of choice, although evidence from Asia suggests that artesunate is associated with a lower mortality. We compared parenteral treatment with either artesunate or quinine in African children with severe malaria. METHODS: This open-label, randomised trial was undertaken in 11 centres in nine African countries....

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
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Journal:
Lancet
Volume:
376
Issue:
9753
Pages:
1647-1657
Publication date:
2010-11-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:001333c7-cd92-44ac-972e-2044db2f5ac9
Source identifiers:
93210
Local pid:
pubs:93210

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