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Thesis

Hepcidin regulation in Malaria

Abstract:

Epidemiological observations have linked increased host iron with malaria susceptibility. At the same time, blood-stage malaria infection is associated with potentially life-threatening anemia. To improve our understanding of these relationships, this work presents an examination of the mechanisms controlling the upregulation of the hormone hepcidin, the master regulator of iron metabolism, in malaria infection. Chapter 2 presents data from a mouse model of malaria infection which indicate...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Inst of Molecular Medicine
Research group:
Dr. Alexander Hal Drakesmith
Oxford college:
Keble College
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Supervisor

More from this funder
Funding agency for:
Spottiswoode, N

Publication date:
2015
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Language:
English
Keywords:
Subjects:
UUID:
uuid:ea5646aa-9c64-4158-9de8-1d6b7fc9d41d
Local pid:
ora:9905
Deposit date:
2015-02-04

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