Applying GRADE in systematic reviews of complex interventions: Challenges and considerations for a new guidance

Thesis

Background: The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach offers a transparent framework for rating the certainty of evidence in systematic reviews. Concerns, however, have been raised that use of GRADE beyond biomedical interventions frequently downgrades the “best evidence possible” for many complex interventions. This DPhil thesis aims to (1) further investigate the challenges of using GRADE in systematic reviews of complex interventi...

Expand abstract

Authors: Movsisyan, A

• DOI: 10.5287/ora-o1zmvnkk9
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Subjects: complex interventions; evidence rating; Systematic reviews (Medical research); GRADE