Thesis

The mechanism of the enzymatic ring expansion of penicillin N to deacetoxycephalosporin C

Abstract:: The order of events in the Deacetoxycephalosporin C/Deacetylcephalosporrn C Synthetase (DAOC/DAC Synthetase) catalysed ring expansion of penicillin N to deacetoxycephalosporin C has been investigated by the use of labelled/unlabelled penicillin N mixed competitive kinetic isotope effect experiments, in which the labelled penicillin N substrates were either labelled in the pro R- and pro S-methyl groups or at C-3. In addition, to assisting in the determina...
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APA Style

Crouch, N., & Crouch, N. P. (1988). The mechanism of the enzymatic ring expansion of penicillin N to deacetoxycephalosporin C [PhD thesis]. University of Oxford.

MLA Style

Crouch, N., and Nicholas P. Crouch. The Mechanism of the Enzymatic Ring Expansion of Penicillin N to Deacetoxycephalosporin C. University of Oxford, 1988.

Chicago Style

Crouch, N, and Nicholas P. Crouch. 1988. “The Mechanism of the Enzymatic Ring Expansion of Penicillin N to Deacetoxycephalosporin C.” PhD thesis, University of Oxford.
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Files:: 602819996.pdf

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Authors

+ Crouch, N More by this author

Institution:: University of Oxford
Division:: MPLS
Role:: Author

+ Nicholas P. Crouch More by this author

Role:: Author

Contributors

Role:: Supervisor

Role:: Supervisor

Publication date:: 1988
Type of award:: DPhil
Level of award:: Doctoral
Awarding institution:: University of Oxford

Language:: English
Subjects:: Cephalosporins

Penicillin

Ring formation (Chemistry)
UUID:: uuid:de3e54eb-b4b5-4673-a863-3c094cc1456d
Local pid:: td:602819996
Source identifiers:: 602819996
Deposit date:: 2014-04-01

Terms of use

Copyright holder:: Nicholas P. Crouch
Copyright date:: 1988
Notes:: This thesis was digitised thanks to the generosity of Dr Leonard Polonsky.

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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